High-precision human immune aging clock identifies RUNX1 as key target for T cell senescence

MedicalXpress | апр 16, 2026

The immune system acts as a critical sentinel of organismal aging, integrating the sensing of physiological states with the execution of defense and clearance functions. Immunosenescence not only reflects systemic functional decline but also serves as a central driver of multiple age-related diseases. However, owing to the high heterogeneity and complexity of the immune system, accurately quantifying its aging status and identifying actionable intervention targets have been major scientific challenges in the field.