Standard-dose antibiotic is the 'preferred choice' of treatment for uncomplicated acute sinusitis
Acute sinusitis leads to more antibiotic prescriptions for U.S. adults than any other condition, but there is no consensus on which antibiotic is preferred for uncomplicated cases. In a retrospective, nationwide study of more than 500,000 patients with acute sinusitis, a research team led by Mass General Brigham investigators found no major differences in measured outcomes between adults who received standard amoxicillin and amoxicillin-clavulanate (a more powerful, combination antibiotic). Patients treated with amoxicillin-clavulanate were at slightly higher risk of contracting secondary infections. Results are published in JAMA.
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