How a gentler stem cell transplant may move type 1 diabetes treatment closer

MedicalXpress | апр 23, 2026

A combination blood stem cell and pancreatic islet cell transplant from an immunologically mismatched donor completely prevented or cured type 1 diabetes in mice in a study by Stanford Medicine researchers. Type 1 diabetes arises when the immune system mistakenly destroys insulin-producing islet cells in the pancreas. None of the animals developed graft-versus-host disease—in which the immune system arising from the donated blood stem cells attacks healthy tissue in the recipient—and the destruction of islet cells by the native host immune system was halted. After the transplants, the animals did not require the use of the immune-suppressive drugs or insulin for the duration of the six-month experiment.