Combination treatment could be safer, more effective for drug overdoses involving severe agitation

MedicalXpress | 四月 26, 2026

A team of Marshall University researchers has published a new study suggesting a potential breakthrough in how doctors manage severe agitation caused by methamphetamine and/or cocaine use, particularly in cases in which opioids have also been used. Michael Hambuchen, PharmD, Ph.D., with Marshall's School of Pharmacy and Todd Davies, Ph.D., at the Joan C. Edwards School of Medicine, are studying the use of dexmedetomidine-naloxone for treatment. Their preclinical study was published in the Journal of Pharmacy of Pharmaceutical Sciences and is available here.