Two-pronged phage treatment counters resistance in Mycobacterium abscessus lung infections

MedicalXpress | Mai 04, 2026

Scientists from A*STAR Infectious Diseases Labs (A*STAR IDL), Nanyang Technological University, Singapore's Lee Kong Chian School of Medicine (LKCMedicine), the National University of Singapore (NUS), and international collaborators have uncovered how Mycobacterium abscessus—a bacterium that causes serious lung infections—can evade bacteriophage (phage) therapy, and demonstrated a combination strategy to overcome this resistance, offering a pathway toward more effective and durable treatments. The study was published in the Proceedings of the National Academy of Sciences.