Direct-to-proteasome strategy degrades two cancer proteins and may curb drug resistance

MedicalXpress | Mai 06, 2026

A preclinical study has developed a strategy that enables the forced elimination of proteins that help tumors survive chemotherapy. This finding opens a new avenue to tackle resistance to cancer treatments, one of the major challenges in oncology. The research, published in Nature Communications, provides a proof of concept for a new mechanism of induced degradation of harmful proteins, expanding the potential for developing more effective therapies in the future.