Genetic risk of schizophrenia manifests in early adolescence, study shows

MedicalXpress | 五月 13, 2026

Research has found that children with higher genetic susceptibility to schizophrenia show decreases in frontal cortical surface area during early adolescence, in contrast to the regional expansion observed in children with low genetic susceptibility. This suggests that individuals with high genetic liability for schizophrenia may already show deviations in their neurodevelopmental trajectories before symptoms typically appear in young adulthood. The findings from the new study in Biological Psychiatry, published by Elsevier, provide critical insights for refining developmental models of schizophrenia and for informing the timing of preventive interventions.