AI-powered atlas reveals new insights into tertiary lymphoid structures as prognostic and response biomarkers in cancer

MedicalXpress | mai 28, 2026

In a study published in Science, researchers from The University of Texas MD Anderson Cancer Center have developed a spatial atlas of specialized immune structures, called tertiary lymphoid structures (TLSs), across multiple cancer types. This first-of-its-kind atlas revealed that TLS maturation state, spatial location and composition within tumors may provide clinically meaningful information about cancer prognosis and treatment response.