Deep brain stimulation boosts myelination and shifts brain networks linked to depression

MedicalXpress | juin 02, 2026

Researchers from the Icahn School of Medicine at Mount Sinai have uncovered the first direct evidence that deep brain stimulation (DBS) can remodel white matter pathways in the brain and alter communication across large-scale neural networks, revealing a previously unrecognized mechanism that may explain how the therapy helps patients recover from severe depression. The study, published June 1 in Nature Neuroscience, provides critical insight into the biological basis of DBS, an emerging therapy for treatment-resistant depression and other neuropsychiatric disorders.