Inflammation may trigger protective cell shift in ulcerative colitis, study finds

MedicalXpress | يون 22, 2026

Paneth cell metaplasia (PCM), long viewed as a consequence of chronic inflammation in ulcerative colitis, may also help protect and repair the intestine, according to researchers at Science Tokyo. The study found that inflammation increases IL-22 signaling, which promotes PCM and the production of REG3A, a protein that helps heal the intestinal lining. The findings suggest PCM may be a protective response but should be monitored because persistent PCM could increase cancer risk.