Uterine aging linked to poorer pregnancy outcomes after 49 despite donor eggs

MedicalXpress | Jul 05, 2026

A major new study suggests that age-related changes in the uterus may contribute to poorer pregnancy outcomes, with women aged 49 and older experiencing lower live birth rates and higher miscarriage risk despite donor-oocyte treatment. Presented at the 42nd Annual Meeting of the European Society of Human Reproduction and Embryology (ESHRE), the findings challenge the assumption that donor eggs can fully "reset" the reproductive clock by eliminating the effects of reproductive aging.