Genome editing in rats enables more accurate estrogen receptor-positive breast cancer models

MedicalXpress | 七月 09, 2026

Rat disease models have played an integral role in scientific discovery and cancer research, including Nobel Prize–winning work from Charles Huggins on hormone therapy for prostate cancer in 1966. However, technical challenges in genetic engineering of rat models have limited their use in research, and over the decades, mouse models have become much more widely used.