Skeletal muscle signals to brain, brown fat to control aging in mice

MedicalXpress | Jul 15, 2026

Open lines of communication between the body's organs are important to health and often falter with age. A new study in mice by researchers at WashU Medicine shows how signals that travel from skeletal muscle to the brain and then activate brown fat and control core body temperature are weakened in elderly mice. The research suggests that finding ways to restore these signals could offer new opportunities to support healthy aging.