Targeting RBM5 may help disrupt 'undruggable' MYC in childhood leukemia

MedicalXpress | 七月 16, 2026

Scientists from St. Jude Children's Research Hospital and collaborators have identified the RNA-binding protein RBM5 as a potential vulnerability in a set of difficult-to-treat childhood leukemias. They characterized how RBM5 regulates and interacts with the well-known cancer-driving protein MYC, which has long been considered impossible to effectively and directly target with existing cancer drugs. The findings, published today in Leukemia, present a new opportunity to develop targeted therapeutic interventions.