Largest genetic analysis of borderline personality disorder identifies 11 risk regions and nine genes

MedicalXpress | juil. 20, 2026

An international team led by the Central Institute of Mental Health in Mannheim has presented the largest genome-wide association study on borderline personality disorder to date. Data from about 13,000 affected people and more than 1.1 million controls from 14 countries were analyzed. The study identified 11 independent risk regions and nine genes that could contribute to the development of the disorder. The findings, published in Nature Genetics, show clear genetic overlaps with other mental and physical illnesses and open new perspectives for research and care.