Rare bone disease often goes untreated while patients quietly live with chronic pain

MedicalXpress | أغس 03, 2026

Teeth and bones are among the hardest structures in the human body, but certain inherited conditions can rob them of that strength. One of them is hypophosphatasia (HPP), a rare, lifelong genetic bone disorder that disrupts the development of bones and teeth, leaving them unusually soft and fragile. A recent study set out to determine how common HPP is across Central and Eastern Europe and how it presents in patients.