New insights into genetic architecture of a rare systemic inflammatory disease in East Asian populations

MedicalXpress | أغس 03, 2026

Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic inflammatory disease characterized by eosinophilia, an abnormal increase in eosinophils—a type of white blood cell—and inflammation of small blood vessels across multiple organs, which can lead to organ damage. The disease is often preceded by asthma or chronic rhinosinusitis and has been designated an intractable disease in Japan.